Total protein may increase with conditions that cause: That increase/expand plasma volume (diluting the blood), such as congestive heart failure.That accelerate the breakdown or loss of protein, such as kidney disease (nephrotic syndrome).Where production of albumin or globulin proteins is impaired, such as malnutrition or severe liver disease.Total protein may decrease in conditions: The level of total protein in the blood is normally a relatively stable value, reflecting a balance in loss of old protein molecules and production of new protein molecules. They include enzymes, antibodies, hormones, carrier proteins, and numerous other types of proteins. The globulin proteins are a varied group. The remaining 40% of proteins in the plasma are referred to as globulins. Produced by the liver, albumin serves a variety of functions including as a carrier protein for many small molecules and ions, as a source of amino acids for tissue metabolism, and as the principle component involved in maintaining osmotic pressure (preventing fluid from leaking out of blood vessels). Albumin makes up about 60% of the total protein. Two classes of proteins are found in the blood, albumin and globulin. This test measures the total amount of the various types of proteins in the liquid (serum or plasma) portion of the blood. They form the structural part of most organs and make up enzymes and hormones that regulate body functions. Proteins are important building blocks of all cells and tissues they are important for body growth, development, and health.
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